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Article

Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells.

Nucleic acids research - 13 Jul 2015

Devailly Guillaume, Grandin Mélodie, Perriaud Laury, Mathot Pauline, Delcros Jean-Guy, Bidet Yannick, Morel Anne-Pierre, Bignon Jean-Yves, Puisieux Alain, Mehlen Patrick, Dante Robert

Abstract excerpt

DNA methylation is thought to induce transcriptional silencing through the combination of two mechanisms: the repulsion of transcriptional activators unable to bind their target sites when methylated, and the recruitment of transcriptional repressors with specific affinity for methylated DNA. The Methyl CpG Binding Domain proteins MeCP2, MBD1 and MBD2 belong to the latter category. Here, we present MBD2 ChIPseq...

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Identifiers

PMID: 26007656
DOI: 10.1093/nar/gkv508
PMCID: PMC4499136

Genes

MBD2
MBD1

Provenance

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