Article

Methyl-CpG binding domain protein 2 plays a causal role in breast cancer growth and metastasis

2020-10-07

Abstract excerpt

Methyl-CpG-binding domain protein 2 (Mbd2), a reader of DNA-methylation, has been implicated in the progression of several types of malignancies, including breast cancer. To test whether Mbd2, which is overexpressed in human breast cancer samples and in MMTV-PyMT mammary pads, plays a causal role in mammary tumor growth and metastasis we depleted Mbd2 in transgenic MMTV-PyMT model of breast cancer by cross-breedin...

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Identifiers and source

Literature Corpus work: 25360534-0b64-54cf-8914-b0f8f0ffbc92
DOI: 10.1101/2020.10.06.328989

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