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Dual genomic localizations and gene regulatory functions of MBD-2 with and without NuRD in Caenorhabditis elegans which lacks DNA methylation.

Nature communications - 20 Jan 2026

Tsui Hok Ning, Wong Charmaine Yan Yu, Zheng Chaogu, Yuen Karen Wing Yee

Abstract excerpt

5-methylcytosine (5mC) DNA methylation is an ancient epigenetic mechanism. Methyl-CpG-binding domain protein 2 or 3 (MBD2/3) is a component of the Nucleosome Remodeling and Deacetylase (NuRD) complex, essential for gene regulation in mammals. The MBD2/3 ortholog is surprisingly preserved even in 5mC-free invertebrates, such as nematodes and flies. We found that Caenorhabditis elegans MBD-2 (Cel-MBD-2), despite...

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PMID: 41559100
DOI: 10.1038/s41467-026-68592-0
PMCID: PMC12923846

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MBD2

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