Article

Methyl-CpG binding domain 2 (Mbd2) is an Epigenetic Regulator of Autism-Risk Genes and Cognition

2018-01-16

Abstract excerpt

The Methyl-CpG-Binding Domain Protein family has been implicated in neurodevelopmental disorders. The Methyl-CpG-binding domain 2 (Mbd2) binds methylated DNA and was shown to play an important role in cancer and immunity. Some evidence linked this protein to neurodevelopment. However, its exact role in neurodevelopment and brain function is mostly unknown. Here we show that Mbd2 -deficiency in mice ( Mbd2 −/−) r...

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Literature Corpus work: 1b521fb8-6ce3-56e1-b476-7f63e24c1805
DOI: 10.1101/247197

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