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Article

p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction.

Nucleic acids research - 1 Jan 2006

Brackertz Marc, Gong Zihua, Leers Jörg, Renkawitz Rainer

Abstract excerpt

The Mi-2/NuRD complex is a multi-subunit protein complex with enzymatic activities involving chromatin remodeling and histone deacetylation. Targeting of Mi-2/NuRD to methylated CpG sequences mediates gene repression. The function of p66alpha and of p66beta within the multiple subunits has not been addressed. Here, we analyzed the in vivo function and binding of both p66-paralogs. Both factors function in...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

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Share to Protein Structure, Tertiary

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Source

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Identifiers

PMID: 16415179
DOI: 10.1093/nar/gkj437
PMCID: PMC1331983

Genes

MBD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction.PMID 16415179Read ↗

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