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Article

Methyl-CpG-binding domain proteins: readers of the epigenome.

Epigenomics - 1 Jan 2015

Du Qian, Luu Phuc-Loi, Stirzaker Clare, Clark Susan J

Abstract excerpt

How DNA methylation is interpreted and influences genome regulation remains largely unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates for the readout of DNA methylation as they recruit chromatin remodelers, histone deacetylases and methylases to methylated DNA associated with gene repression. MBD protein binding requires both functional MBD domains and methyl-CpGs; however,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25927341
DOI: 10.2217/epi.15.39

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