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MBD2 Ablation Impairs Lymphopoiesis and Impedes Progression and Maintenance of T-ALL

12 Jan 2018

Abstract excerpt

Abstract Aberrant DNA methylation patterns in leukemia might be exploited for therapeutic targeting. In this study, we employed a genetically deficient mouse model to explore the role of the methylated DNA binding protein MBD2 in normal and malignant hematopoiesis. MBD2 ablation led to diminished lymphocytes. Functional defects of the lymphoid compartment were also observed after in vivo reconstitution of...

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PMID: 29330145
DOI: 10.1158/0008-5472.can-17-1434

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