Article
MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters.
Molecular and cellular biology - 1 Mar 2003
Lembo Francesca, Pero Raffaela, Angrisano Tiziana, Vitiello Carmen, Iuliano Rodolfo, Bruni Carmelo B, Chiariotti Lorenzo
Abstract excerpt
We have identified a human gene encoding a novel MBD2-interacting protein (MBDin) that contains an N-terminal GTP-binding site, a putative nuclear export signal (NES), and a C-terminal acidic region. MBDin cDNA was isolated through a two-hybrid interaction screening using the methyl-CpG-binding protein MBD2 as bait. The presence of the C-terminal 46-amino-acid region of MBD2 and both the presence of the acidic...
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