Article
Imprinting control region (ICR) of the Peg3 domain.
Human molecular genetics - 15 Jun 2012
Kim Joomyeong, Ekram Muhammad B, Kim Hana, Faisal Mohammad, Frey Wesley D, Huang Jennifer M, Tran KimNgoc, Kim Michelle M, Yu Sungryul
Abstract excerpt
The imprinting and transcription of the 500 kb genomic region surrounding the mouse Peg3 is predicted to be regulated by the Peg3-differentially methylated region (DMR). In the current study, this prediction was tested using a mutant mouse line lacking this potential imprinting control region (ICR). At the organismal level, paternal and maternal transmission of this knockout (KO) allele caused either reduced or...
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