Article
Novel method for simultaneous analysis of p53 and K-ras mutations and p53 protein expression in single histologic sections.
Archives of pathology & laboratory medicine - 1 Mar 2001
Yamashita K, Yoshida T, Shinoda H, Okayasu I
Abstract excerpt
BACKGROUND AND OBJECTIVE: Abnormal protein expression and gene mutation should be examined on exactly identified lesions. To perform simultaneous analyses of oncogene or tumor suppressor gene mutations and related protein expression in single histologic sections, we have developed a novel method using an antigen-retrieval solution for a polymerase chain reaction template before immunohistochemical staining....
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