Article
Polymerase chain reaction-based approaches for detection of allelic loss in the p53 tumor suppressor gene in colon neoplasms.
The American journal of gastroenterology - 1 Feb 1997
Yamaguchi K, Sugano K, Fukayama N, Nakashima Y, Saotome K, Yokoyama T, Yokota T, Ohkura H
Abstract excerpt
OBJECTIVES: Inactivation of the p53 tumor suppressor gene is considered to be a late event involved in the malignant transformation of colorectal adenoma to cancer. Thus, its detection is thought to provide useful information for the clinical management of colorectal neoplasms. We devised a rapid screening test for allelic loss of the p53 gene by non-radioisotopic single-strand conformation polymorphism analysis....
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