Article
Polymerase chain reaction-based approaches for detection of allelic loss in the p53 tumor suppressor gene in colon neoplasms.
The American journal of gastroenterology - 1 Feb 1997
Yamaguchi K, Sugano K, Fukayama N, Nakashima Y, Saotome K, Yokoyama T, Yokota T, Ohkura H
Abstract excerpt
OBJECTIVES: Inactivation of the p53 tumor suppressor gene is considered to be a late event involved in the malignant transformation of colorectal adenoma to cancer. Thus, its detection is thought to provide useful information for the clinical management of colorectal neoplasms. We devised a rapid...
Topics
- Adenocarcinoma
- Adenoma
- Adenoma, Villous
- Alleles
- Amino Acid Sequence
- Base Sequence
- Colonic Neoplasms
- DNA, Neoplasm
- Exons
- Gene Frequency
- Genes, p53
- Heterozygote
- Humans
- Introns
- Molecular Sequence Data
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational