Article
Molecular detection of APC, K- ras, and p53 mutations in the serum of colorectal cancer patients as circulating biomarkers.
World journal of surgery - 1 Jul 2004
Wang Jaw-Yuan, Hsieh Jan-Sing, Chang Mei-Yin, Huang Tsung-Jen, Chen Fang-Ming, Cheng Tian-Lu, Alexandersen Ketil, Huang Yu-Sheng, Tzou Wen-Shyong, Lin Shiu-Ru
Abstract excerpt
Early detection of tumor DNA in serum/plasma prior to the development of recurrence or metastases could help improve the outcome of patients with colorectal cancer (CRC) after tumor resection. Recent advances in the detection of tumor DNA in the serum/plasma has opened up numerous new areas for investigation and new possibilities for molecular diagnosis. APC and K- ras mutations are considered to be early-stage...
Topics
- Aged
- Colorectal Neoplasms
- Female
- Genes, APC
- Genes, p53
- Genes, ras
- Humans
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational