Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A rapid and nonisotopic method for the screening and sequencing of p53 gene mutations in formalin-fixed, paraffin-embedded tumors.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 1997

Soong R, Iacopetta B J

Abstract excerpt

Evaluation of the clinical significance of p53 gene mutations requires molecular analysis of primary tumors from large series of patients with long follow-up periods. In this study, we describe a sensitive, rapid, nonisotopic and inexpensive procedure for the polymerase chain reaction (PCR)-single-stranded conformational polymorphism (SSCP) detection and subsequent sequencing of p53 mutations in formalin-fixed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Genes, p53

Share to Mutation

Share to Paraffin Embedding

Share to Polymerase Chain Reaction

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 9071734

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A rapid and nonisotopic method for the screening and sequencing of p53 gene mutations in formalin-fixed, paraffin-embedded tumors.PMID 9071734Read ↗

Molecular approach to rapid assessment of p53 tumor suppressor mutations in esophageal tumors from stained histological slides.Semantic proximity Read ↗

Detection of mutations and polymorphisms in the p53 tumor suppressor gene by single-strand conformation polymorphism analysis.Semantic proximity Read ↗

DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known p53 alterations in human malignancies.Semantic proximity Read ↗

A comprehensive system to explore p53 mutations.Semantic proximity Read ↗

Detection of p53 gene mutation by rapid PCR-SSCP and its association with poor survival in breast cancer.Semantic proximity Read ↗

Novel method for simultaneous analysis of p53 and K-ras mutations and p53 protein expression in single histologic sections.Semantic proximity Read ↗

Non-isotopic detection of single-stranded conformation polymorphisms using ethidium bromide/UV light.Semantic proximity Read ↗

Single-step DGGE-based mutation scanning of the p53 gene: application to genetic diagnosis of colorectal cancer.Semantic proximity Read ↗

Multiplex PCR-SSCP for simultaneous screening for mutations in several exons of p53.Semantic proximity Read ↗

Screening of the entire coding region of p53 in low grade lymphoproliferative disorders.Semantic proximity Read ↗

TP53 gene mutations in gastric carcinoma detected by polymerase chain reaction/single-strand conformation polymorphism analysis of archival material.Semantic proximity Read ↗

Identification of p53 mutations in archival prostate tumors. Sensitivity of an optimized single-strand conformational polymorphism (SSCP) assay.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.