Article
Rapid, efficient genotyping of clinical tumor samples by laser-capture microdissection/PCR/SSCP.
Experimental and molecular pathology - 1 Jun 2001
Dillon D, Zheng K, Costa J
Abstract excerpt
BACKGROUND: Mutation analysis is becoming increasingly important in clinical practice, since sporadic mutations in tumors often correlate with prognosis and/or therapeutic response. However, the labor-intensive nature of the molecular analyses has limited the routine clinical use of tumor genotyping. Laser-capture microdissection (LCM) allows procurement of relatively pure tumor cell populations. We have...
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