Article
Novel polymerase chain reaction approach for full-coding p53 mutation detection in microdissected archival tumors.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Jun 2000
Thompson-Hehir J, Davies M P, Green J A, Halliwell N, Joyce K A, Salisbury J, Sibson D R, Vergote I, Walker C
Abstract excerpt
Evidence suggests that up to 25% of p53 mutations are outside of exons 5-8 and that insertions, deletions, and polymorphic sites in the p53 gene may play a significant role in the process of carcinogenesis. A novel polymerase chain reaction (PCR) approach for the analysis of the entire p53 coding and splice site regions from microdissected, formalin-fixed, paraffin-embedded tumor tissues has been developed which...
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