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Article

Analysis of K-ras codon 12 mutations and p53 overexpression in colorectal nodule-aggregating tumors.

Journal of gastroenterology and hepatology - 1 Oct 2000

Kusaka T, Fukui H, Sano Y, Ueda Y, Chiba T, Fujimori T

Abstract excerpt

BACKGROUND AND AIMS: Morphologically, colorectal nodule-aggregating tumors are quite different from polypoid-type colorectal tumors that develop via the adenoma-carcinoma sequence. Although polypoid-type colorectal tumors are well known to have a high incidence of K-ras gene mutation and p53 overexpression, colorectal nodule-aggregating tumors have not been examined in terms of genetic changes and...

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PMID: 11106095
DOI: 10.1046/j.1440-1746.2000.02280.x

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