Article
Multiple detection of genetic alterations in tumors and stool.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2001
Rengucci C, Maiolo P, Saragoni L, Zoli W, Amadori D, Calistri D
Abstract excerpt
Detection of genetic alterations in exfoliated intestinal cells in stool could represent an alternative, noninvasive tool for the screening of colorectal tumors. To verify this, we analyzed p53 and K-ras mutations and microsatellite instability on 46 cases of colorectal cancer and compared the presence of molecular alterations in tumor tissue and stool samples from individual patients. p53 exons 5-8 and K-ras...
Topics
- Colorectal Neoplasms
- DNA Mutational Analysis
- Electrophoresis, Polyacrylamide Gel
- Exons
- Feces
- Genes, p53
- Genes, ras
- Humans
- Microsatellite Repeats
- Mutation
- Neoplasms