Article
p53 tumor suppressor gene status and the degree of genomic instability in sporadic colorectal cancers.
Journal of the National Cancer Institute - 20 Nov 1996
Kahlenberg M S, Stoler D L, Basik M, Petrelli N J, Rodriguez-Bigas M, Anderson G R
Abstract excerpt
BACKGROUND: Genomic instability reflects the propensity and the susceptibility of the genome to acquire multiple alterations and, in turn, is believed to be a driving force behind multistep carcinogenesis. Although the molecular basis of genomic instability in sporadic colorectal cancers remains...
Topics
- Chromosome Aberrations
- Chromosome Breakage
- Chromosome Deletion
- Colorectal Neoplasms
- DNA, Neoplasm
- Female
- Genes, p53
- Humans
- Male
- Mutation
- Polymerase Chain Reaction
- Translocation, Genetic