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Article

Structural identification of a key protective B-cell epitope in Lyme disease antigen OspA.

Journal of molecular biology - 6 Oct 2000

Ding W, Huang X, Yang X, Dunn J J, Luft B J, Koide S, Lawson C L

Abstract excerpt

Outer surface protein A (OspA) is a major lipoprotein of the Borrelia burgdorferi spirochete, the causative agent of Lyme disease. Vaccination with OspA generates an immune response that can prevent bacterial transmission to a mammalian host during the attachment of an infected tick. However, the protective capacity of immune sera cannot be predicted by measuring total anti-OspA antibody. The murine monoclonal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11183781
DOI: 10.1006/jmbi.2000.4119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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