Article

Mechanistic insights into structure-based design of a Lyme disease subunit vaccine

2024-10-28

Abstract excerpt

<h4>ABSTRACT</h4> The quality of protective immunity plays a critical role in modulating vaccine efficacy, with native antigens often not able to trigger sufficiently strong immune responses for pathogen killing. This warrants creation of structure-based vaccine design, leveraging high-resolution antigen structures for mutagenesis to improve protein stability and efficient immunization strategies. Here, we invest...

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Identifiers and source

Literature Corpus work: c9e2282f-cda3-559d-a45d-295698f8969f
DOI: 10.1101/2024.10.23.619738

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