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Article

Structural Basis for the Immunogenic Properties of the Meningococcal Vaccine Candidate LP2086

23 Dec 2008

Abstract excerpt

LP2086 is a family of outer membrane lipoproteins from Neisseria meningitidis, which elicits bactericidal antibodies and are currently undergoing human clinical trials in a bivalent formulation where each antigen represents one of the two known LP2086 subfamilies. Here we report the NMR structure of the recombinant LP2086 variant B01, a representative of the LP2086 subfamily B. The structure reveals a novel fold...

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PMID: 19103601
DOI: 10.1074/jbc.m808831200

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