Article

Single-domain antibodies reveal unique borreliacidal epitopes on the Lyme disease vaccine antigen, Outer surface protein A (OspA)

2024-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Camelid-derived, single-domain antibodies (V H Hs) have proven to be extremely powerful tools in defining the antigenic landscape of immunologically heterogeneous surface proteins. In this report, we generated a phage-displayed V H H library directed against the candidate Lyme disease vaccine antigen, Outer surface protein A (OspA). Two alpacas were immunized with recombinant OspA serotype 1 (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6d10cd03-9718-5523-a7b5-c8bf366c9e52
DOI: 10.1101/2024.01.23.576890

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-domain antibodies reveal unique borreliacidal epitopes on the Lyme disease vaccine antigen, Outer surface protein A (OspA)DOI 10.1101/2024.01.23.576890Read

Single-domain antibodies reveal unique borrelicidal epitopes on the Lyme disease vaccine antigen, outer surface protein A (OspA)Semantic proximity Read

A Broadly Conserved Protective Epitope on the Lyme Disease Vaccine Antigen, OspASemantic proximity Read

Development of novel multi-protein chimeric immunogens that protect against infection with the Lyme disease agent, Borreliella burgdorferiSemantic proximity Read

Alpaca Single B Cell Interrogation and Heavy-Chain-Only Antibody Discovery on an Optofluidic PlatformSemantic proximity Read

Clonal diversification in OspA-specific antibodies from peripheral circulation of a chronic Lyme arthritis patient.Semantic proximity Read

Shark Variable New Antigen Receptor (VNAR) Single Domain Antibody Fragments: Stability and Diagnostic ApplicationsSemantic proximity Read

Structural and molecular analysis of a protective epitope of Lyme disease antigen OspA and antibody interactions.Semantic proximity Read

Maximum Antigen Diversification in a Lyme Bacterial Population and Evolutionary Strategies to Overcome Pathogen DiversitySemantic proximity Read

Mechanistic insights into structure-based design of a Lyme disease subunit vaccineSemantic proximity Read

Subtractive Proteomics and Reverse-Vaccinology Approaches for Novel Drug Target Identification and Chimeric Vaccine Development against Bartonella henselae Strain Houston-1Semantic proximity Read

Development, High-Throughput Profiling, and Biopanning of a Large Phage Display Single-Domain Antibody LibrarySemantic proximity Read

Structural identification of a key protective B-cell epitope in Lyme disease antigen OspA.Semantic proximity Read