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Article

Structural and molecular analysis of a protective epitope of Lyme disease antigen OspA and antibody interactions.

Journal of molecular recognition : JMR - 1 May 2017

Shandilya Shivender, Kurt Yilmaz Nese, Sadowski Andrew, Monir Ejemel, Schiller Zachary A, Thomas William D, Klempner Mark S, Schiffer Celia A, Wang Yang

Abstract excerpt

The murine monoclonal antibody LA-2 recognizes a clinically protective epitope on outer surface protein (OspA) of Borrelia burgdorferi, the causative agent of Lyme disease in North America. Human antibody equivalence to LA-2 is the best serologic correlate of protective antibody responses following OspA vaccination. Understanding the structural and functional basis of the LA-2 protective epitope is important for...

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Topics

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Share to Antibodies, Monoclonal, Murine-Derived
Share to Antigens, Surface

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bacterial Outer Membrane Proteins

Share to Bacterial Vaccines

Share to Borrelia burgdorferi

Share to Lipoproteins

Share to Lyme Disease

Share to Structural Homology, Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 27859766
DOI: 10.1002/jmr.2595
PMCID: PMC5383521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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