Article

A Broadly Conserved Protective Epitope on the Lyme Disease Vaccine Antigen, OspA

2025-12-25

Abstract excerpt

<h4>ABSTRACT</h4> Lyme disease, caused by the spirochete, Borreliella burgdorferi sensu latu (Bbsl), is a debilitating tickborne infection of increasing incidence in North America, Europe and Asia. While vaccines based on Outer surface protein A (OspA) have proven highly efficacious at blocking Bbsl tick-to-human transmission, the high degree of antigenic variability among the major OspA serotypes (ST) has made...

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Literature Corpus work: bd1e7fb9-f77e-54f4-8a44-0bf5c9d2c740
DOI: 10.64898/2025.12.24.696337

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