Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive seroprofiling of sixteen B. burgdorferi OspC: implications for Lyme disease diagnostics design.

Clinical immunology (Orlando, Fla.) - 1 Sept 2009

Ivanova Larisa, Christova Iva, Neves Vera, Aroso Miguel, Meirelles Luciana, Brisson Dustin, Gomes-Solecki Maria

Abstract excerpt

Early diagnosis of Lyme disease (LD) is critical to successful treatment. However, current serodiagnostic tests do not reliably detect antibodies during early infection. OspC induces a potent early immune response and is also one of the most diverse proteins in the Borrelia proteome. Yet, at least 70% of the amino acid sequence is conserved among all 21 known OspC types. We performed a series of comprehensive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Bacterial
Share to Cross Reactions

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunodominant Epitopes

Share to Immunoglobulin M

Share to Lyme Disease

Share to Mice, Inbred C3H

Share to Peromyscus

Share to Serologic Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 19576856
DOI: 10.1016/j.clim.2009.05.017
PMCID: PMC2752154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive seroprofiling of sixteen B. burgdorferi OspC: implications for Lyme disease diagnostics design.PMID 19576856Read ↗

Phenotypic analysis of outer surface protein C (OspC) of Borrelia burgdorferi sensu lato by monoclonal antibodies: relationship to genospecies and OspA serotype.Semantic proximity Read ↗

Four clones of Borrelia burgdorferi sensu stricto cause invasive infection in humans.Semantic proximity Read ↗

Identification of Borrelia burgdorferi ospC genotypes in canine tissue following tick infestation: implications for Lyme disease vaccine and diagnostic assay design.Semantic proximity Read ↗

Development of novel multi-protein chimeric immunogens that protect against infection with the Lyme disease agent, Borreliella burgdorferiSemantic proximity Read ↗

Demonstration of OspC Type Diversity in Invasive Human Lyme Disease Isolates and Identification of Previously Uncharacterized Epitopes That Define the Specificity of the OspC Murine Antibody ResponseSemantic proximity Read ↗

Outer surface protein C is a dissemination-facilitating factor of Borrelia burgdorferi during mammalian infection.Semantic proximity Read ↗

A Broadly Conserved Protective Epitope on the Lyme Disease Vaccine Antigen, OspASemantic proximity Read ↗

Diversity of the Lyme Disease Spirochetes and its Influence on Immune Responses to Infection and VaccinationSemantic proximity Read ↗

Identification and quantification of Lyme pathogen strains by deep sequencing of outer surface protein C ( <i>ospC</i> ) ampliconsSemantic proximity Read ↗

Genotyping and Quantifying Lyme Pathogen Strains by Deep Sequencing of the Outer Surface Protein C (ospC) Locus.Semantic proximity Read ↗

Molecular diversity of the ospC gene in Borrelia. Impact on phylogeny, epidemiology and pathology.Semantic proximity Read ↗

Immunological and molecular polymorphisms of OspC, an immunodominant major outer surface protein of Borrelia burgdorferiSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.