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An Fc-silent OspA monoclonal antibody passively protects mice from tick and intradermal <i>Borrelia burgdorferi</i> challenge

2025-12-16

Abstract excerpt

<h4>ABSTRACT</h4> The monoclonal antibody, LA-2, has played a pivotal role in the development of O uter s urface p rotein A (OspA)-based vaccines for Lyme disease, a multisystem illness caused by the tick-borne spirochete, Borrelia burgdorferi sensu lato. Of particular significance was the demonstration more than three decades ago that LA-2 equivalent antibody titers, defined by a competitive-inhibition ELIS...

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Literature Corpus work
cfced912-2c79-519f-a066-01ba8e63e6c7
DOI
10.64898/2025.12.14.694235
Open publication

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