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Single-domain antibodies reveal unique borrelicidal epitopes on the Lyme disease vaccine antigen, outer surface protein A (OspA)

17 Mar 2024

Abstract excerpt

ABSTRACT Camelid-derived, single-domain antibodies (V H Hs) have proven to be extremely powerful tools in defining the antigenic landscape of immunologically heterogeneous surface proteins. In this report, we generated a phage-displayed V H H library directed against the candidate Lyme disease vaccine antigen, outer surface protein A (OspA). Two alpacas were immunized with recombinant OspA serotype 1 from...

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PMID: 38470113
DOI: 10.1128/iai.00084-24

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