Article
Alpha2-macroglobulin polymorphisms in Italian sporadic and familial Alzheimer's disease.
Neuroscience letters - 16 Feb 2001
Nacmias B, Tedde A, Cellini E, Forleo P, Orlacchio A, Guarnieri B M, Petruzzi C, D'Andrea F, Serio A, Sorbi S
Abstract excerpt
A 5-bp deletion and a Val1000 polymorphism at the alpha(2)-macroglobulin (A2M) gene have recently been reported to be associated with late onset Alzheimer's disease (AD). As recently it has been suggested that the effect of the A2M gene on AD susceptibility may be limited to certain populations or families, we analyzed the segregation of A2M and apolipoprotein E polymorphisms in Italian sporadic and familial AD....
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