Article
The alpha2-macroglobulin gene in AD: a population-based study and meta-analysis.
Neurology - 12 Sept 2000
Koster M N, Dermaut B, Cruts M, Houwing-Duistermaat J J, Roks G, Tol J, Ott A, Hofman A, Munteanu G, Breteler M M, van Duijn C M, Van Broeckhoven C
Abstract excerpt
BACKGROUND: Whereas several authors recently reported a positive association between the alpha2-macroglobulin gene (A2M) and late-onset AD (LOAD), others were unable to replicate these findings. Early-onset AD (EOAD) is defined as onset age <65 years. Virtually all patients with LOAD are >65 years of age. OBJECTIVE: To evaluate the role of A2M in AD, the authors conducted a population-based study of EOAD and LOAD...
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