Alpha-2 macroglobulin is genetically associated with Alzheimer disease.

doi:10.1038/1243

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Article

Alpha-2 macroglobulin is genetically associated with Alzheimer disease.

Nature genetics - 1 Aug 1998

Blacker D, Wilcox M A, Laird N M, Rodes L, Horvath S M, Go R C, Perry R, Watson B, Bassett S S, McInnis M G, Albert M S, Hyman B T, Tanzi R E

Abstract excerpt

Alpha-2-macroglobulin (alpha-2M; encoded by the gene A2M) is a serum pan-protease inhibitor that has been implicated in Alzheimer disease (AD) based on its ability to mediate the clearance and degradation of A beta, the major component of beta-amyloid deposits. Analysis of a deletion in the A2M g...

Topics

Age of Onset
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Chromosomes, Human, Pair 12
Family
Gene Frequency
Genetic Linkage
Genetic Testing
Genotype
Humans
Lod Score
Logistic Models
Risk Factors
alpha-Macroglobulins

Source

Open in PubMed

Identifiers

PMID: 9697696
DOI: 10.1038/1243

Genes

APOE
APP
LRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9697696-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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