Article
On the lack of a clear-cut association between alpha-2-macroglobulin deletion and the risk of Alzheimer disease in Poland.
Folia neuropathologica - 1 Jan 2014
Michałowska-Wender Grażyna, Wawrzynek Alicja, Rossa Grzegorz, Kozubski Wojciech, Wender Mieczysław
Abstract excerpt
Alzheimer disease (AD) is a complex, multi-factorial disease with the potential involvement of several genes. Alpha-2- macroglobulin (A2M) has been implicated in AD on the basis of its ability to mediate the clearance and degradation of -amyloid peptide. Nevertheless, it is not clear whether there are racial differences in frequency of polymorphisms of A2M in AD. We examined a group of 50 unrelated patients from...
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