Article
Lack of association between alpha2-macroglobulin polymorphisms and Alzheimer's disease.
Human genetics - 1 Feb 2001
Wang X, Luedecking E K, Minster R L, Ganguli M, DeKosky S T, Kamboh M I
Abstract excerpt
This study was undertaken to investigate the role of two alpha2-macroglobulin (A2M) polymorphisms, an intronic 5-bp deletion and Ile1000Val, in the development of Alzheimer's disease (AD) and to evaluate the interaction between the apolipoprotein E (APOE) and A2M polymorphisms. The A2M polymorphisms were screened by using polymerase-chain-reaction-based assays in 555 white late-onset AD cases and 446 controls....
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