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Article

Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels.

Biophysical journal - 1 Feb 2001

Slesinger P A

Abstract excerpt

The weaver mutation (G156S) in G-protein-gated inwardly rectifying K+ (GIRK) channels alters ion selectivity and reveals sensitivity to inhibition by a charged local anesthetic, QX-314, applied extracellularly. In this paper, disrupting the ion selectivity in another GIRK channel, chimera I1G1(M), generates a GIRK channel that is also inhibited by extracellular local anesthetics. I1G1(M) is a chimera of IRK1...

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Identifiers

PMID: 11159438
DOI: 10.1016/S0006-3495(01)76050-X
PMCID: PMC1301269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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