Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The selectivity filter may act as the agonist-activated gate in the G protein-activated Kir3.1/Kir3.4 K+ channel.

The Journal of biological chemistry - 12 Dec 2003

Claydon Thomas W, Makary Samy Y, Dibb Katharine M, Boyett Mark R

Abstract excerpt

The Kir3.1/Kir3.4 channel is activated by Gbetagamma subunits released on binding of acetylcholine to the M2 muscarinic receptor. A mechanism of channel opening, similar to that for the KcsA and Shaker K+ channels, has been suggested that involves translocation of pore lining transmembrane helice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electrophysiology
Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels
Share to Oocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenylalanine

Share to Potassium Channels

Share to Potassium Channels, Inwardly Rectifying

Share to Xenopus

Source

Identifiers

PMID: 14525972
DOI: 10.1074/jbc.M308183200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14525972-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The selectivity filter may act as the agonist-activated gate in the G protein-activated Kir3.1/Kir3.4 K+ channel.PMID 14525972Read ↗

Base of pore loop is important for rectification, activation, permeation, and block of Kir3.1/Kir3.4.Semantic proximity Read ↗

Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling.Semantic proximity Read ↗

Potassium channel gating in the absence of the highly conserved glycine of the inner transmembrane helix.Semantic proximity Read ↗

Selective exclusion and selective binding both contribute to ion selectivity in KcsA, a model potassium channel.Semantic proximity Read ↗

A selectivity filter mutation provides insights into gating regulation of a K+ channel.Semantic proximity Read ↗

Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter.Semantic proximity Read ↗

Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity.Semantic proximity Read ↗

Discrete M3-M4 intracellular loop subdomains control specific aspects of γ-aminobutyric acid type A receptor function.Semantic proximity Read ↗

Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels.Semantic proximity Read ↗

Interaction between GABAA receptor α1 and β2 subunits at the N-terminal peripheral regions is crucial for receptor binding and gating.Semantic proximity Read ↗

Residues and mechanisms for slow activation and Ba2+ block of the cardiac muscarinic K+ channel, Kir3.1/Kir3.4.Semantic proximity Read ↗

Mutation in pore-helix modulates interplay between filter gate and Ba2+ block in a Kcv channel pore.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.