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Article

The inwardly rectifying K(+) channel subunit GIRK1 rescues the GIRK2 weaver phenotype.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Oct 1999

Hou P, Yan S, Tang W, Nelson D J

Abstract excerpt

The weaver (wv) gene has been identified as a glycine to serine substitution at residue 156 in the H5 region of inwardly rectifying K(+) channel, GIRK2. The mutation is permissive for the expression of homotetrameric channels that are nonselective for cations and G-protein-independent. Coexpression of GIRK2wv with GIRK1, GIRK2, or GIRK3 in Xenopus oocytes along with expression of subunit combinations linked as...

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PMID: 10493734
PMCID: PMC6783034

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