Article

A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K <sup>+</sup> channel

2021-08-19

Abstract excerpt

G-protein-gated inwardly rectifying K + (GIRK; Kir3.x) channels play important physiological roles in various organs. Some of the disease-associated mutations of GIRK channels are known to induce loss of K + selectivity but their structural changes remain unclear. In this study, we investigated the mechanisms underlying the abnormal ion selectivity of inherited GIRK mutants. By the two-electrode voltage-clamp an...

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Literature Corpus work: 30e70980-2a50-58d1-be13-5c750d2997db
DOI: 10.1101/2021.08.18.456735

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