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Article

Inhibition of G-protein-coupled inward rectifying K+ channels by intracellular acidosis.

The Journal of biological chemistry - 28 Feb 2003

Mao Jinzhe, Wu Jianping, Chen Fuxue, Wang Xueren, Jiang Chun

Abstract excerpt

G-protein-coupled inward rectification K(+) (GIRK) channels play an important role in modulation of synaptic transmission and cellular excitability. The GIRK channels are regulated by diverse intra- and extracellular signaling molecules. Previously, we have shown that GIRK1/GIRK4 channels are activated by extracellular protons. The channel activation depends on a histidine residue in the M1-H5 linker and may play...

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PMID: 12501240
DOI: 10.1074/jbc.M211461200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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