Article
Biophysical effects of pore mutations of ROMK1.
Clinical science (London, England : 1979) - 1 Aug 2001
Bhandari S, Hunter M
Abstract excerpt
Potassium channels are ubiquitous, being present in all living organisms. These proteins share common structural elements, which confer common functional features. In general, all K+ channels have a high selectivity for K+, and are blocked by cations of similar dimensions, such as Cs+ and Ba2+. Mutations in the pore region tend to lead to either the total loss of function or K+ selectivity. We have made mutations...
Topics
- Animals
- Barium
- Cell Membrane Permeability
- Cesium
- Female
- Glycine
- Linear Models
- Mutation
- Oocytes
- Patch-Clamp Techniques
- Polymerase Chain Reaction
- Potassium Channels
- Potassium Channels, Inwardly Rectifying
- RNA, Complementary
- Xenopus