Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice.

doi:10.1371/journal.pbio.3003172

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Article

Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice.

PLoS biology - 1 Jun 2025

Kanaya Hiroyuki J, Kuwajima Ken, Ito Yuko, Shinohara Yuta, Okubo Yohei, Shiono Shinnosuke, Tatsuki Fumiya, Ohno Rei-Ichiro, Ukai Hideki, Ukai-Tadenuma Maki, Sumiyama Kenta, Fujishima Hiroshi, Yamada Rikuhiro G, Tone Daisuke, Kiyonari Hiroshi, Kikuchi Masaki, Umehara Takashi, Murayama Takashi, Kanemaru Kazunori, Iino Masamitsu, Ode Koji L, Hirokawa Takatsugu, Ueda Hiroki R

Abstract excerpt

Inhaled anesthetics were first introduced into clinical use in the 1840s. Molecular and transgenic animal studies indicate that inhaled anesthetics act through several ion channels, including γ-aminobutyric acid type A receptors (GABAARs) and two-pore domain K+ (K2P) channels, but other targets may mediate anesthetic effects. Mutations in the type 1 ryanodine receptor (RyR1), which is a calcium release channel on...

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Topics

Animals
Isoflurane
Ryanodine Receptor Calcium Release Channel
Anesthetics, Inhalation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice

Anesthesia

Malignant Hyperthermia

Reflex, Righting

Mutation

Mice, Transgenic

Male

Mice, Inbred C57BL

Gene Knock-In Techniques

Source

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Identifiers

PMID: 40460053
DOI: 10.1371/journal.pbio.3003172
PMCID: PMC12132946

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