A region of the muscarinic-gated atrial K+ channel critical for activation by G protein beta gamma subunits.

doi:10.1016/0896-6273(94)90041-8

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Article

A region of the muscarinic-gated atrial K+ channel critical for activation by G protein beta gamma subunits.

Neuron - 1 Sept 1994

Takao K, Yoshii M, Kanda A, Kokubun S, Nukada T

Abstract excerpt

Complementary DNAs encoding two types of inwardly rectifying K+ channels, GIRK1 and IRK1, have been cloned from rat atrium and mouse macrophage, respectively. GIRK1 expressed in Xenopus oocytes was activated by acetylcholine when m2 muscarinic acetylcholine receptor was coexpressed. The acetylcho...

Topics

Animals
Base Sequence
Chimera
GTP-Binding Proteins
Heart Atria
Ion Channel Gating
Macrophages
Mice
Molecular Probes
Molecular Sequence Data
Mutation
Myocardium
Oocytes
Potassium Channels
Rats
Receptors, Muscarinic
Xenopus laevis

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