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Article

A region of the muscarinic-gated atrial K+ channel critical for activation by G protein beta gamma subunits.

Neuron - 1 Sept 1994

Takao K, Yoshii M, Kanda A, Kokubun S, Nukada T

Abstract excerpt

Complementary DNAs encoding two types of inwardly rectifying K+ channels, GIRK1 and IRK1, have been cloned from rat atrium and mouse macrophage, respectively. GIRK1 expressed in Xenopus oocytes was activated by acetylcholine when m2 muscarinic acetylcholine receptor was coexpressed. The acetylcholine-induced activation of GIRK1 was enhanced by coexpression with the G protein beta 1 gamma 2 subunit but not the...

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PMID: 7917304
DOI: 10.1016/0896-6273(94)90041-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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A region of the muscarinic-gated atrial K+ channel critical for activation by G protein beta gamma subunits.PMID 7917304Read ↗

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Importance of the G protein gamma subunit in activating G protein-coupled inward rectifier K(+) channels.Semantic proximity Read ↗

A novel ubiquitously distributed isoform of GIRK2 (GIRK2B) enhances GIRK1 expression of the G-protein-gated K+ current in Xenopus oocytes.Semantic proximity Read ↗

Gbeta residues that do not interact with Galpha underlie agonist-independent activity of K+ channels.Semantic proximity Read ↗

Critical determinants of the G protein gamma subunits in the Gbetagamma stimulation of G protein-activated inwardly rectifying potassium (GIRK) channel activity.Semantic proximity Read ↗

The inwardly rectifying K(+) channel subunit GIRK1 rescues the GIRK2 weaver phenotype.Semantic proximity Read ↗

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