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Article

Tetracaine reports a conformational change in the pore of cyclic nucleotide-gated channels.

The Journal of general physiology - 1 Nov 1997

Fodor A A, Black K D, Zagotta W N

Abstract excerpt

Local anesthetics are a diverse group of clinically useful compounds that act as pore blockers of both voltage- and cyclic nucleotide-gated (CNG) ion channels. We used the local anesthetic tetracaine to probe the nature of the conformational change that occurs in the pore of CNG channels during the opening allosteric transition. When applied to the intracellular side of wild-type rod CNG channels expressed in...

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Identifiers

PMID: 9348330
DOI: 10.1085/jgp.110.5.591
PMCID: PMC2229390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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