Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The sensitivity of G protein-activated K+ channels toward halothane is essentially determined by the C terminus.

The Journal of biological chemistry - 13 Aug 2004

Milovic Sergej, Steinecker-Frohnwieser Bibiane, Schreibmayer Wolfgang, Weigl Lukas G

Abstract excerpt

G protein-activated K(+) channels (GIRKs or Kir3.x) are targets for the volatile anesthetic, halothane. When coexpressed with the m(2) acetylcholine (ACh) receptor in Xenopus oocytes, agonist-activated GIRK1(F137S)- and GIRK2-mediated currents are inhibited by halothane, whereas in the absence of ACh, high concentrations of halothane induce GIRK1(F137S)-mediated currents. To elucidate the molecular mechanism of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anesthetics, Inhalation
Share to Electrophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

Share to Halothane

Share to Potassium Channels

Share to Potassium Channels, Inwardly Rectifying

Share to RNA, Complementary

Share to Xenopus laevis

Source

Identifiers

PMID: 15175324
DOI: 10.1074/jbc.M403448200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The sensitivity of G protein-activated K+ channels toward halothane is essentially determined by the C terminus.PMID 15175324Read ↗

Determinants of the anesthetic sensitivity of neuronal nicotinic acetylcholine receptors.Semantic proximity Read ↗

Inhalational anaesthetics and n-alcohols share a site of action in the neuronal Shaw2 Kv channel.Semantic proximity Read ↗

Importance of the gamma-aminobutyric acid(B) receptor C-termini for G-protein coupling.Semantic proximity Read ↗

Subunit-dependent block by isoflurane of wild-type and mutant alpha(1)S270H GABA(A) receptor currents in Xenopus oocytes.Semantic proximity Read ↗

Blockage of one class of potassium channel alters the effectiveness of halothane in a brain circuit of Drosophila.Semantic proximity Read ↗

Functional properties of a truncated recombinant GIRK5 potassium channel.Semantic proximity Read ↗

A region of the muscarinic-gated atrial K+ channel critical for activation by G protein beta gamma subunits.Semantic proximity Read ↗

Effects of isoflurane on gamma-aminobutyric acid type A receptors activated by full and partial agonists.Semantic proximity Read ↗

A Single phenylalanine residue in the main intracellular loop of α1 γ-aminobutyric acid type A and glycine receptors influences their sensitivity to propofol.Semantic proximity Read ↗

The effects of isoflurane on desensitized wild-type and alpha 1(S270H) gamma-aminobutyric acid type A receptors.Semantic proximity Read ↗

Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity.Semantic proximity Read ↗

Ligand-induced signal transduction within heterodimeric GABA(B) receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.