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Article

PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma.

International journal of cancer - 1 Jan 2001

Salvesen H B, MacDonald N, Ryan A, Jacobs I J, Lynch E D, Akslen L A, Das S

Abstract excerpt

Loss of heterozygosity and mutations in the PTEN (MMAC1) tumor suppressor gene are frequent in endometrial carcinoma. Promoter hypermethylation has recently been identified as an alternative mechanism of tumor suppressor gene inactivation in cancer, but its importance in the PTEN gene in endometrial carcinoma is unknown. The purpose of our study was to assess the frequency of promoter methylation of the PTEN gene...

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Source

Identifiers

PMID: 11149415
DOI: 10.1002/1097-0215(20010101)91:1<22::aid-ijc1002>3.0.co;2-s

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma.PMID 11149415Read ↗

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Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing.Semantic proximity Read ↗

Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles.Semantic proximity Read ↗

Status and significance of CpG island methylator phenotype in endometrial cancer.Semantic proximity Read ↗

Mutational analysis of the PTEN gene in endometrial carcinoma and hyperplasia.Semantic proximity Read ↗

PTEN/MMAC1 mutations in endometrial cancers.Semantic proximity Read ↗

Promoter region methylation and loss of protein expression of PTEN and significance in cervical cancerSemantic proximity Read ↗

The relationship between microsatellite instability and PTEN gene mutations in endometrial cancer.Semantic proximity Read ↗

Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers.Semantic proximity Read ↗

The PTENP1 Pseudogene, Unlike the PTEN Gene, Is Methylated in Normal Endometrium, As Well As in Endometrial Hyperplasias and Carcinomas in Middle-Aged and Elderly FemalesSemantic proximity Read ↗

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