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Article

Racial disparity in the frequency of PTEN mutations, but not microsatellite instability, in advanced endometrial cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2000

Maxwell G L, Risinger J I, Hayes K A, Alvarez A A, Dodge R K, Barrett J C, Berchuck A

Abstract excerpt

Survival of African Americans with endometrial cancer is significantly worse than that of whites. Mutation of the PTEN tumor suppressor gene and microsatellite instability occur in some endometrial cancers, and they are associated with favorable prognostic features. The aim of this study was to determine whether there is a racial disparity in the frequency of these molecular alterations that contributes to...

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Source

Identifiers

PMID: 10955777

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Racial disparity in the frequency of PTEN mutations, but not microsatellite instability, in advanced endometrial cancers.PMID 10955777Read ↗

Racial differences in oncogene mutations detected in early-stage low-grade endometrial cancers.Semantic proximity Read ↗

PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics.Semantic proximity Read ↗

PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma.Semantic proximity Read ↗

Association of specific PTEN/10q haplotypes with endometrial cancer phenotypes in African-American and European American women.Semantic proximity Read ↗

PTEN mutation: A potential prognostic factor associated with immune infiltration in endometrial carcinoma.Semantic proximity Read ↗

Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing.Semantic proximity Read ↗

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.Semantic proximity Read ↗

TP53 mutation and abnormal p53 expression in endometrial cancer: Associations with race and outcomes.Semantic proximity Read ↗

PTEN loss is a context‐dependent outcome determinant in obese and non‐obese endometrioid endometrial cancer patientsSemantic proximity Read ↗

Somatic gene mutations in African Americans may predict worse outcomes in colorectal cancer.Semantic proximity Read ↗

Loss of PTEN expression is associated with metastatic disease in patients with endometrial carcinomaSemantic proximity Read ↗

The relationship between microsatellite instability and PTEN gene mutations in endometrial cancer.Semantic proximity Read ↗

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