Article
Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles.
Japanese journal of cancer research : Gann - 1 Aug 1998
Kurose K, Bando K, Fukino K, Sugisaki Y, Araki T, Emi M
Abstract excerpt
Loss of heterozygosity (LOH) of chromosome 10q is observed in approximately 40% of endometrial cancers. Mutations in PTEN/MMAC1, a gene recently isolated from the 10q23 region, are responsible for two dominantly inherited neoplastic syndromes, Cowden disease and Bannayan-Zonana syndrome. Somatic...
Topics
- Alleles
- Chromosomes, Human, Pair 10
- Endometrial Neoplasms
- Female
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Humans
- Loss of Heterozygosity
- Mutation
- Neoplasm Proteins
- PTEN Phosphohydrolase
- Phosphoric Monoester Hydrolases
- Protein Tyrosine Phosphatases
- Tumor Suppressor Proteins