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Article

Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers.

Cancer research - 1 May 2004

Goel Ajay, Arnold Christian N, Niedzwiecki Donna, Carethers John M, Dowell Jeannette M, Wasserman Linda, Compton Carolyn, Mayer Robert J, Bertagnolli Monica M, Boland C Richard

Abstract excerpt

Loss of PTEN tumor suppressor function is observed in tumors of breast, prostate, thyroid, and endometrial origin. Allelic losses in the proximity of the PTEN locus (10q23) also occur in sporadic colorectal cancers (CRCs), but biallelic inactivation of this site has not been frequently demonstrated. We hypothesized that alternative mechanisms of PTEN allelic inactivation, such as promoter hypermethylation, might...

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Share to Chromosomes, Human, Pair 10
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15126336
DOI: 10.1158/0008-5472.can-2401-2

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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