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Article

Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2012

Djordjevic Bojana, Hennessy Bryan T, Li Jie, Barkoh Bedia A, Luthra Rajyalakshmi, Mills Gordon B, Broaddus Russell R

Abstract excerpt

PTEN (phosphatase and tensin homolog) is a tumor suppressor that negatively regulates the PI3K-AKT signaling pathway, which is implicated in the pathogenesis of endometrial carcinoma. Sanger sequencing has been considered to be the gold standard for detection of PTEN sequence abnormalities. However, this approach fails to address the epigenetic mechanisms that contribute to functional PTEN loss. Using a study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22301702
DOI: 10.1038/modpathol.2011.208
PMCID: PMC3341518

Genes

PTEN

Provenance

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Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing.PMID 22301702Read ↗

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