Article
Mutational analysis of the PTEN gene in endometrial carcinoma and hyperplasia.
American journal of clinical pathology - 1 Jan 2001
Sun H, Enomoto T, Fujita M, Wada H, Yoshino K, Ozaki K, Nakamura T, Murata Y
Abstract excerpt
To determine the potential role of PTEN in the process of endometrial carcinogenesis, we examined a series of endometrial carcinoma and hyperplasia of the uterine corpus for the presence of a PTEN mutation. The entire coding region of the gene was screened for the presence of mutations by single-strand conformation polymorphism analysis, and mutations were confirmed by sequencing. We detected mutations in 14 of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.