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Promoter region methylation and loss of protein expression of PTEN and significance in cervical cancer

16 Jun 2014

Abstract excerpt

The genetic basis underlying cervical tumorigenesis and progression are largely unknown. Phosphatase and tensin homologue (PTEN) is a tumor suppressor gene, and genetic changes of PTEN occurs in various types of cancer suggesting that the inactivation of PTEN may play an important role in the pathogenesis of a variety of human malignancies. In the present study, 102 cervical cancer specimens were examined for the...

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PMID: 25054006
DOI: 10.3892/br.2014.298

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