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Article

The Glu298Asp polymorphism of the NOS 3 gene as a determinant of the baseline production of nitric oxide.

Journal of hypertension - 1 Oct 2002

Veldman Bart A, Spiering Wilko, Doevendans Peter A, Vervoort Gerald, Kroon Abraham A, de Leeuw Peter W, Smits Paul

Abstract excerpt

RATIONALE: The endothelial nitric oxide synthase Glu298Asp polymorphism has been suggested to play a role in the development of hypertension, atherosclerosis and coronary artery disease. OBJECTIVE: To investigate functional differences between the various genotypes with respect to basal nitric oxide (NO) production, we estimated the response to endothelial NO synthase (ecNOS) inhibition by infusion of increasing...

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PMID: 12359981
DOI: 10.1097/00004872-200210000-00022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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